منابع مشابه
Macrophage lipoprotein receptors.
Macrophages possess a number of surface receptors that are capable of mediating the internalization of lipoproteins. The low-density lipoprotein (LDL) receptor of human monocyte macrophages recognizes apolipoprotein B-100 and apolipoprotein E and is rapidly regulated in response to changes in intracellular cholesterol levels. In contrast, in J774 macrophages LDL receptor regulation is defective...
متن کاملLipoprotein receptors, macrophages, and sphingomyelinase.
Cholesteryl ester–filled macrophages are the hallmark of atherosclerotic lesions. Unraveling the pathways responsible for lipid accumulation in macrophages has been viewed as an important aspect for understanding a piece of the atherosclerotic process.1 Investigations into the mechanisms through which macrophages accumulate cholesteryl esters from lipoproteins have delineated the involvement of...
متن کاملLipoprotein Receptors Signaling Functions in the Brain?
brain has a characteristic architecture of packed layers of cells with specific functional identities. In VLDLR Ϫ apoER2 Ϫ , reln Ϫ , and dab1 Ϫ brains, these layers are disorganized. For example, the Purkinje cells of the cerebellum normally migrate outward from an origin near the fourth While some nutrients enter cells through transporters, ventricle, to form a thin layer beneath cerebellar g...
متن کاملRegulation of Low Density Lipoprotein Receptors
Membranes prepared from the adrenal gland of mice and rats possess high affinity binding sites that recognize '261-labeled human low density lipoprotein (LDL). These binding sites resemble the functional LDL receptors that mediate the uptake of LDL by cultured mouse and bovine adrenal cells. The number of LDL binding sites per mg of membrane protein increased 2to 5-fold over 24 h when mice or r...
متن کاملReelin Is a Ligand for Lipoprotein Receptors
A signaling pathway involving the extracellular protein Reelin and the intracellular adaptor protein Disabled-1 (Dab1) controls cell positioning during mammalian brain development. Here, we demonstrate that Reelin binds directly to lipoprotein receptors, preferably the very low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2). Binding requires calcium, and it is inh...
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ژورنال
عنوان ژورنال: Cell
سال: 1999
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)80778-3